Description
MORF4L1(mortality factor 4-like protein 1), also known as MRG15, belongs to the MRG family. This protein is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. MORF4L1 is a transcription factor expressed in a variety of human tissues, and its orthologs have been found in many other eukaryotes which constitute the MRG protein family. The C-terminal part of MRG15 forms a conserved MRG domain which is involved in interactions with the tumor suppressor protein retinoblastoma and a nucleoprotein. Recombinant human MORF4L1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography